Figure 5.

Cell uptake of APMS is an active process not involving clathrin- or caveolae-mediated mechanisms. Flow cytometry after incubation of MM cells at 4°C or 37°C and with or without selective inhibitors (pretreatment for 30 min before addition of APMS) were used to evaluate the percentage of cells positive for APMS uptake at 30 min (open bars) or 4 h (solid bars). Mean ± SEM from at least three individual experiments. ^#P < 0.05; *P < 0.01 when compared with 37°C group at respective time point.