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. 2006 Dec 29;36(5):552–561. doi: 10.1165/rcmb.2006-0320OC

Figure 6.

Figure 6.

ALK-5 inhibitor stimulates branching morphogenesis and blocks TGF-β1 inhibition of branching morphogenesis. E12.5 lung explants were pretreated with 20 μM SB431542 for 1 h, followed by incubation with 100 ng/ml TGF-β1 for 48 h. Representative photomicrographs of lung explants are shown: (A) control explant; (B) explant treated with 100 ng/ml TGF-β1; (C) explant incubated with SB431542; (D) explant incubated with both SB431542 and TGF-β1. (E) Graphical representation of the quantification of terminal branching at 48 h. Each bar represents mean ± SD from six explants. SB431542 stimulated branching and blocked TGF-β1 inhibition of branching. *P < 0.001 compared with control; **P < 0.001 compared with TGF-β1 treatment. SB, SB431542.