Figure 5.

Inhibition of NO-mediated vasodilation of intact cerebral arteries by DT-2 and DT-3. Pressurized segments of rat posterior cerebral artery were dilated with the NO donor NONOate (1 nM to 1 mM, indicated by arrows) in the presence or absence of the fusion peptides DT-2 and DT-3 for 25 min. (A) Continuous diameter tracings are shown for untreated, DT-2 treated, and DT-3 treated vessels. (B) NONOate dose–response curves in untreated arteries (n = 11) or arteries exposed to DT-2 (n = 6) or DT-3 (n = 6).