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. Author manuscript; available in PMC: 2008 Jun 1.
Published in final edited form as: J Virol Methods. 2007 Feb 15;142(1-2):50–58. doi: 10.1016/j.jviromet.2007.01.006

Figure 6. Comparison of MCMV IgG1 antibody responses to infection in different mouse strains.

Figure 6

Mice were injected with A. 5 × 104 PFU of Smith strain murine cytomegalovirus (MCMV), or B. 1 × 105 m157 deletion mutant MCMV (Δm157). Sera were collected and analyzed 2, 4, 8, and 20 weeks after infection for MCMV specific antibody by flow cytometry. A. MCMV antibody responses to Smith MCMV infection were significantly higher in BALB/c mice than in C57BL/6 mice at all time points (all p<0.0001). B. Similarly, BALB/c mice infected with Δm157 MCMV had significantly higher antibody responses than C57BL/6 mice at all time points (all p<0.003), despite having equal tissue viral titers (not shown). Antibody binding is expressed as percentage of GFP infected target cells that co-localized anti-MCMV antibody. Each data point represents results from n=10 mice.