Table 3.
Phenotype-Genotype Correlations in PCG Patients of Iran and India
| Mutation* | Onset by birth†
|
Corneal diameter (mm) ‡
|
IOP (mm Hg)‡
|
C/D ratio‡§
|
||||
|---|---|---|---|---|---|---|---|---|
| India | Iran | India | Iran | India¶ | Iran∥ | India | Iran | |
| G61E | 3 (3) | 9 (15) | 3.9 (6) | 13.4 (29) | 30.2 (6) | 29.1 (28) | 0.48 (4) | 0.49 (15) |
| R368H | 17 (19) | 1 (2) | 13.0 (38) | 15.3 (3) | 26.1 (36) | 29.7 (3) | 0.48 (20) | 0.87 (3) |
| R390C | 5 (5) | 12.5 (8) | 26.6 (10) | 0.30 (2) | ||||
| R390H | 5 (8) | 12.7 (24) | 33.4 (24) | 0.65 (8) | ||||
| R469W | 2 (3) | 13.9 (8) | 30.0 (14) | 0.60 (6) | ||||
Data for patients from India based on Ref. 35.
*
All homozygous.
†
Number of patients (no. of patients with the mutation).
‡
Average of eyes for which data is available (no. of eyes for which data is available).
§
Cup/disc ratio of the optic nerve.
¶
IOP at diagnosis.
∥
Maximum IOP.