Table 4.
Alignment of Novel Amino Acid Variations in Cytochrome P450 Proteins
| Variation | Q109R | A202D | D291G | G329V | R368C | I399V | Seq ID* |
|---|---|---|---|---|---|---|---|
| CYP1A1_Human | QALVRQGD | VVSVTNVIC | EK-GHIRDIT | IVLDLFGAGFDTVTTAIS | RKIQEELDTVIGRSRRPRLS | VPFTIPHST | sp P04798 |
| CYP1A1_Mouse | QALVRQGD | VVSVANVIC | EK-GHIRDIT | IVLDLFGAGFDTVTTAIS | RKIQEELDTVIGRDRQPRLS | VPFTIPHST | sp P00184 |
| CYP1A1_Rat | QALVKQGD | VVSVANVIC | EK-GHIRDIT | IVFDLFGAGFDTITTAIS | RKIQEELDTVIGRDRQPRLS | VPFTIPHST | sp P00185 |
| CYP1A1_Monkey | QALVQQGD | VISVANVIC | EK-GHIRDIT | VVLDLFGAGFDTVTTAIS | RKIQEELDTVIGRSRRPRLS | VPFTIPHST | sp Q6GUR1 |
| CYP1A1_Dog | QALVRQGD | VVSVANVIC | EK-GQIRDVT | VVLDLFGAGFDTVTTAIS | KKIQKELDTVIGRARQPRLS | VPFTIPHST | sp P56590 |
| CYP1A1_Sheep | QALVRQGD | VVSVANVIC | EK-GHIRDIT | VVMDLFGAGFDTVTTAIS | KKIQEELDTVIGRARWPQLS | VPFTIPHST | sp P56591 |
| CYP1A1_Guinea pig | QALVRQGD | VVSVANVIS | EK-GHIRDIT | IVLDLFGAGFDTITTAIS | KKIQEELDTVIGRERQPQLA | MPFTIPHST | sp Q06367 |
| CYP1A1_Hamster | QALVRQGD | VVSVTNVIC | EK-GHIRDIT | IIVDLFGAGFDTVTTAIS | RKIQEELDTVIGRSRRPRLC | LPFTIPHST | sp Q00557 |
| CYP1A1_Rabbit | QALVRQGD | VMSVANVIC | EK-GHIRDIT | IVLDLFGAGFDTVTTAIS | RKIQEELDAVVGRARRPRFS | LPFTIPHST | sp P05176 |
| CYP1A1_Sea bream | QALIKQGD | VVSVANVIC | DK-DNIRDIT | IVNDLFGAGFDTISTALS | ERLYQEMKESVGLDRTPCLS | LPFTIPHCS | sp O42457 |
| CYP1A1_Scup | QALIKQGD | VVSVANVIC | DK-DNIRDIT | IVNDLFGAGFDTISTALS | ERLYQEMNETVGPDRTPCLS | LPFTIPHCT | sp Q92116 |
| CYP1A1_Plaice | QALIKQGD | VVSVANVIC | NK-DNIRDIT | IVNDLFGAGFDTVSTALS | ERLYQEIEDKVGLDRMPLLS | LPFTIPHCT | sp Q92100 |
| CYP1A1_Oyster | QALIKQGE | VVSVANVIC | NK-DNIRDIT | IVNDLFGAGFDTVSTGLS | ERLYQEIKDSVGTERMPLLS | LPFTIPHCT | sp Q92095 |
| CYP1A1_Trout | QALIKQGE | VVSVANVIC | DK-DNIRDIT | IVNDLFGAGFDTISTALS | ERLHQELKEKVGMIRTPRLS | LPFTIPHCT | sp Q92110 |
| CYP1A1_Tomcod | QALIKQGH | VVSVANVIC | DK-DNIRDIT | IVNDLFGAGFDTVSTALS | ERLHQEIKDKVGLSRSPVLT | LPFTIPHCA | sp Q92148 |
| CYP1A2_Human | QALVRQGD | VVSVANVIG | DK-NSVRDIT | LVNDIFGAGFDTVTTAIS | RKIQKELDTVIGRERRPRLS | LPFTIPHST | sp P05177 |
| CYP1A2_Dog | QALVRQGD | LLSVANVIG | DE-RSVQDIT | LINDIFGAGFDTVTTAIS | RQIQKELDTVIGRARQPRLS | VPFTIPHST | sp P56592 |
| CYP1A2_Rabbit | QALVRQGD | VVSAARVIG | DR-NSIQDIT | LVNDIFGAGFDTITTALS | RKIQEELDAVVGRARQPRLS | VPFTIPHST | sp P00187 |
| CYP1A2_Mouse | QALVRQGD | VESVANVIG | NK-NSIQDIT | IVNDIFGAGFDTVTTAIT | RKIHEELDTVVGRDRQPRLS | VPFTIPHST | sp P00186 |
| CYP1A2_Rat | QALVKQGD | VESVANVIG | NK-NSIQDIT | IVNDIFGAGFETVTTAIF | RKIHEELDTVIGRDRQPRLS | VPFTIPHST | sp P04799 |
| CYP1A2_Hamster | QALVRQGD | VESVANVIG | NK-NSIQDIT | IVNDLFGAGFDTVTTAIT | RKIHKELDTVIGRDRQPRLS | VPFTIPHST | sp P24453 |
| CYP1A2_Guinea pig | QALVRQSD | VGSVANVIG | DK-NHVQDIA | LVNDIFGAGFDTVTTAIS | KKIHKELDAVIGRDRKPRLA | LPFTIPHCT | sp Q64391 |
| CYP1A3_Trout | QALIKQGE | VVSVANVIC | DK-DNIRDIT | IVNDLFGAGFDTISTALS | ERLHQELKEKVGMIRTPRLS | LPFTIPHCT | sp Q92109 |
| CYP1A4_Chicken | QALVRQAE | MVSVANVIC | DK-EHIRDVT | IVNDLFGAGFDTVTTALS | KKIQAELDQTIGRERRPRLS | LPFTIPHCT | sp P79760 |
| CYP1A5_Chicken | QALVRQAE | VVSVANVIC | DK-NNIRDVT | LVNDIFGAGFDTVTTALS | KKIQAELDQTIGRERRPRLS | MPFTIPHST | sp P79761 |
| CYP1B1_Human | QALVQQGS | VVAVANVMS | RPGAAPRDMM | TITDIFGASQDTLSTALQ | TRVQAELDQVVGRDRLPCMG | VPVTIPHAT | sp Q16678 |
| CYP1B1_Mouse | QALVQQGS | IVAVANVMS | VPGAAPRDMT | TITDIFGASQDTLSTALL | ARVQAELDQVVGRDRLPCMS | LPVTIPHAT | sp Q64429 |
| CYP1B1_Rat | QALVQQGG | IVAVANVMS | VPGAAPRDMM | TITDIFGASQDTLSTALL | ARVQAELDQVVGRDRLPCMS | LPVTLPHAT | sp Q64678 |
| CYP1B1_Dolphin | -------- | -----NVMS | RPGAAPRDMM | TVTDIFGASQDTLSTALQ | ARVQAELDQVVGRDRLPCLD | VPVTIPHAT | tr Q8SQH0 |
| CYP1B_Plaice | QALVKQGT | VVSTANIMS | QS-STTRDMT | TMGDIFGASQDTLSTALQ | LRIQQEVDKVVDRTRLPSIE | VPLTIPHST | tr Q9W713 |
| CYP1B_Zebrafish | -------- | --------- | ---------- | --------SQDTLSTALQ | KRLQEDVDRVVDRSRLPTIA | TPLTIPHST | tr Q8QFQ1 |
| CYP1C1_Scup | EALIQHST | TVAAANIMC | DP-EVTRDMS | TVTDLIGAGQDTVSTVMQ | AKLQELIDKVVGQDRLPSIE | VPVTIPHST | tr Q8QGR5 |
| CYP1C2_Scup | EALIQHST | TVAAANVIC | DP-EVTRDIS | TVSDLIGAGLDTVSTALH | TKLHELIDKVVGRQRLPSIE | VPVTIPHST | tr Q8QGR1 |
| CYP2V1_Zebrafish | KVLNDQGN | NNGVSNIIC | DP-SSPRDFI | AVLDLFVAGTETTSTTLL | EKVQAEIDKVVGRYRRPSMD | VPLSVPRMT | tr Q4L203 |
*
Sequence ID numbers at Expasy server (http://www.expasy.org/sprot/).