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Assessment of Individual Methylation Markers
| Marker | Overall ranking | Sum of four rank order numbers | Rank for the sum of sensitivity and specificity
|
Rank for false-positive and -negative cases
|
||
|---|---|---|---|---|---|---|
| CIMP-high cutoff
| ||||||
| ≥6/8 | ≥5/8 | ≥6/8 | ≥5/8 | |||
| RUNX3 | 1 | 4.5 | 1 | 1 | 1.5* | 1 |
| CACNA1G | 2 | 11 | 2 | 3 | 3 | 3 |
| IGF2 | 2 | 11 | 3 | 2 | 4 | 2 |
| MLH1 | 4 | 19.5 | 7 | 7 | 1.5* | 4 |
| NEUROG1 | 5 | 21 | 4 | 5 | 6 | 6 |
| CRABP1 | 6 | 23 | 5 | 4 | 7 | 7 |
| SOCS1 | 7 | 26 | 8 | 8 | 5 | 5 |
| CDKN2A | 8 | 28 | 6 | 6 | 8 | 8 |
Average of rank order numbers 1 and 2.
