Figure 4.

The effect of miR-21 inhibitor 2′OMe-miR-21 on cardiac myocyte hypertrophy. A: Inhibition of miR-21 expression by miR-21 inhibitor 2′OMe-miR-21 (30 nmol/L). The mean MiR-21 level in vehicle-treated cells is defined as 1. B: The effect of miR-21 inhibitor 2′OMe-miR-21 on cardiac myocyte size in Ang II- or PE-treated cells. The mean myocyte size in vehicle-treated cells is defined as 1. C: The effect of miR-21 inhibitor 2′OMe-miR-21 on cardiac myocyte protein synthesis in Ang II- or PE-treated cells. The mean value of [³H]leucine incorporation in vehicle-treated cells are defined as 1. D: Representative cell pictures from different treatment groups. *P < 0.05 compared with vehicle control; ^#P < 0.05 compared with Ang II-treated group; P < 0.05 compared with PE-treated group.