Figure 6.

In vivo studies: clinical outcome. Graphs in a and b show the capillary density and arteriole numerical density, respectively, expressed as number of capillaries or the number of arterioles per square millimeter of transverse muscular section. Values of normoperfused (no ischemia, open column) and ischemic adductor muscles injected with CM or transplanted with 2 × 10⁴ hVPCs are shown. Values are mean ± SD. **P < 0.01 versus no ischemia; ^§P < 0.05 versus CM, EPCs, and differentiated hVPCs; *P < 0.05 versus no ischemia. c: The percentage of sectional area occupied by myocytes was determined by computer-assisted morphometric evaluation of muscular sections. hVPC transplantation significantly reduced the loss of myocytes. Values are mean ± SD. ^§P < 0.05 versus CM, EPCs, and differentiated hVPCs; ^#P < 0.05 hVPCs versus no ischemia; *P < 0.05 versus no ischemia. d: hVPCs improved the perfusion of adductor muscles subjected to left limb surgical ischemia. BF of left (ischemic) and right (contralateral normoperfused control) adductors was measured by the OxyLite/OxyFlo probe at 14 days postischemia. BF recovery was calculated as the ratio of left to right BF multiplied per 100. Mice transplanted with hVPCs showed improved perfusion recovery versus all of the control groups. Values are mean ± SD. ^§P < 0.05 versus CM, EPCs, and differentiated hVPCs.