Figure 5.

Clinical appearance of SKH1 mice injected with anti-CMP EBA antibodies. A–F: SKH1 mice were injected intradermally with EBA antibodies at 50 μg/g body weight once every day for 8 consecutive days. Eight to 12 days after the injections were started, animals developed numerous blisters, erosions, and crusts forming from ruptured blisters (A and B, days 8 and 12 after eight injections; C and D, days 8 and 13 after eight injections). E: Lesions were observed on the animals’ ears at 14 days after the initial injections (eight injections). F: Nail loss was also observed in some mice.