Table 2.

Effects of Met-RANTES Treatment on ALT Levels and Hepatic Recruitment of CCR1-Positive NK Cells in Con A-Treated CCR5 KO Mice

Treatment groups	ALT (U/L)	CCR1-positive NK cells × 105
PBS + WT	612 ± 58.1	0.31 ± 0.05
PBS + CCR5 KO	13,020 ± 112*	0.71 ± 0.10*
Met-RANTES + CCR5 KO	454 ± 32#	0.35 ± 0.05#

CCR5 KO mice were injected intravenously with either PBS or Met-RANTES (30 μg/mouse) as described in Materials and Methods. In addition, WT mice were injected with PBS. All mice were sacrificed at 8 hours after Con A administration for determination of plasma ALT levels and the number of CCR1-expressing NK cells in the liver as described in Materials and Methods. All data (n = 4 per group) are presented as means ± SEM. 

^*P < 0.05 versus WT mice. 

^#P < 0.05 versus PBS/CCR5 KO mice.