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. 2007 Jun;170(6):2001–2008. doi: 10.2353/ajpath.2007.061016

Figure 2.

Figure 2

Leukocyte infiltration and demyelination are reduced in CD11c−/− mice in EAE. Spinal cords from wild-type and CD11c−/− mice (n = 3 for each group) were obtained at 32 days after immunization, fixed in 10% buffered formalin, and paraffin-embedded. Sections from the cervical, thoracic, and lumbar regions (5 μm) were stained with H&E or Luxol fast blue (LFB) and scored as described in Materials and Methods. A: Representative section from a wild-type mouse stained with H&E. Arrows indicate widespread cellular infiltration and inflammation. B: Section from the same specimen as in A stained with LFB. Arrows indicates regions of significant demyelination. C: Representative section from an CD11c−/− mouse stained with H&E. Note the lack of cellular infiltration and inflammation. D: Section from the same specimen as in C stained with LFB. Little to no demyelination was observed throughout the white matter. Original magnifications, ×4.