Table 4.
Effect of AT1R Antagonist (AT1RA) or Hydralazine on Blood Pressure in Anti-Nephrin Antibody-Induced Nephropathy
| Treatment | Pre | Day 3 | Day 5 | Day 13 |
|---|---|---|---|---|
| Systolic blood pressure | ||||
| AT1RA (n = 7) (mmHg) | 122.8 ± 7.8 | 108.5 ± 8.1† | 114.9 ± 7.9* | 113.8 ± 9.8* |
| Vehicle (n = 7) (mm Hg) | 125.1 ± 9.7 | 124.0 ± 6.1 | 124.1 ± 4.1 | 124.8 ± 6.9 |
| Mean blood pressure | ||||
| AT1RA (n = 7) (mm Hg) | 95.8 ± 8.4 | 81.3 ± 7.0† | 88.4 ± 7.2* | 87.2 ± 8.2 |
| Vehicle (n = 7) (mm Hg) | 97.3 ± 12.3 | 94.6 ± 4.9 | 96.8 ± 4.4 | 95.2 ± 6.0 |
| Diastolic blood pressure | ||||
| AT1RA (n = 7) (mm Hg) | 82.5 ± 10.7 | 67.8 ± 7.6† | 75.3 ± 7.4 | 74.0 ± 7.8 |
| Vehicle (n = 7) (mm Hg) | 82.5 ± 10.7 | 79.8 ± 5.3 | 83.2 ± 6.3 | 80.5 ± 6.4 |
| Systolic blood pressure | ||||
| Hydralazine (n = 5) (mm Hg) | 110.9 ± 5.8 | 73.7 ± 4.0§ | 103.9 ± 8.9† | 105.1 ± 4.4† |
| Vehicle (n = 5) (mm Hg) | 113.3 ± 2.8 | 119.7 ± 10.5 | 128.1 ± 7.7 | 119.3 ± 7.7 |
| Mean blood pressure | ||||
| Hydralazine (n = 5) (mm Hg) | 81.7 ± 5.7 | 55.7 ± 3.0§ | 81.9 ± 10.9* | 81.8 ± 4.3 |
| Vehicle (n = 5) (mm Hg) | 83.1 ± 3.5 | 89.8 ± 9.2 | 99.4 ± 5.6 | 92.8 ± 10.1 |
| Diastolic blood pressure | ||||
| Hydralazine (n = 5) (mm Hg) | 67.1 ± 5.9 | 46.9 ± 4.8‡ | 68.3 ± 9.3* | 70.1 ± 4.6 |
| Vehicle (n = 5) (mm Hg) | 68.0 ± 5.1 | 74.9 ± 8.8 | 85.1 ± 6.9 | 79.6 ± 11.7 |
Mean ± SD,
*
P < 0.05,
†
P < 0.01,
‡
P < 0.001,
§
P < 0.0001 versus vehicle group at the same time point.