Figure 4.
Effect of E2, 2ME and BE-3-3-3 on Akt phosphorylation levels in MCF-7 cells. Cells were treated with E2, or E2 + 2ME/BE-3-3-3 combinations for 24 h. Cells were harvested and the lysate was analyzed by sequential Western blots using antibodies specific to phospho-Akt, total Akt, PTEN and β-actin. Similar results were obtained from 3 separate experiments.