TABLE 1.

Properties of yeast adhesins

Species	Adhesin (molecules per haploid cell)	Ligand (affinitya)	Known physiological function(s)	Reference(s)
S. cerevisiae	a-Agglutinin (104-105)b	α-Agglutinin (10−9 M [r, p, c])	Mating	10, 41, 52, 106
	α-Agglutinin (104-105)c	a-Agglutinin (10−9 M [r, p, c])	Mating	10, 78, 134, 141
	Flo1p	α-Mannosides	Flocculation	5, 112, 116, 131
	Flo5p	α-Mannosides	Flocculation	4, 118
	Flo9p	α-Mannosides	Flocculation	41, 117
	Flo10p	α-Mannosides	Flocculation	41, 117
	Flo11p (106)d		Cell-cell adhesion in flocs, pseudohyphae, and biofilms; agar invasion; adhesion to plastic	3, 41, 72, 81, 82, 101
	Fig2p	Unknown	Mating	41, 59, 138
	Lg-Flo1p		Flocculation	67
C. albicans	Als1p		Aggregation, binding endothelia and epithelia	27, 39, 47, 60
	Als3p		Biofilm formation	90, 92, 142
	Als5p	(10−4 M to synthetic peptides [c])	Aggregation, binding epithelia	35, 49, 65, 99, 107
	Other Als proteins			38, 39, 47, 48, 50, 51, 139, 142, 143
	Eap1p	Hydrophobic surfaces	Adhesion to plastic	75, 76
	Hwp1p	Substrate for tranglutaminase	Binds epithelia	90, 110
C. glabrata	Epa adhesins	β-Galactosides	Binds epithelia	18, 21, 61

^aAffinity estimates were derived by radioligand binding (r), plasmon resonance (p), and/or 50% inhibitory concentration for competitive ligand (c).

^bMeasured for S. cerevisiae strains W303-1A and X2180-1A.

^cMeasured for S. cerevisiae strains W303-1B and X2180-1B.

^dStrain Σ1278b (Sungsu Lee and A. M. Dranginis, unpublished data).