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Cells lacking p85 are resistant to ER stress. (A) WT or Pik3r1−/− immortalized fibroblasts were serum starved overnight before a 4-h incubation with tunicamycin as indicated. The cells were then treated with insulin for 15 min as indicated. Lysates from the treated cells were then analyzed by Western blot assay with phospho-JNK and phospho-Akt antibodies. (B) Cells were treated as in panel A, except with a 4-h incubation with anisomycin, as indicated.
