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The N terminus of p85α is required for cdc42 activation. Primary hepatocytes were isolated from lox/lox or L-Pik3r1KO mice and then infected with control LacZ, WT p85α, ΔSH3, ΔΒΗ, or ΔΔp85α adenovirus (Adeno). (A) Western blot assay with the pan-p85 antibody confirming expression levels of the construct. PI3K activity (B) and cdc42 activity (C) were measured in insulin-stimulated lysates of the infected primary hepatocytes. The bars represent the SEM (n = 3 to 4).
