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. 2007 Feb 12;27(8):3165–3175. doi: 10.1128/MCB.01315-06

FIG. 8.

FIG. 8.

Schematic indicating how CD8-IGF-IR leads to EMT. This model is based upon studies presented in this report indicating that CD8-IGF-IR induces NF-κB, Snail, repression of E-cadherin mRNA and protein levels, and subsequently, EMT. The hierarchy is shown by the reversion of Snail mRNA levels and EMT by IGF-IR or NF-κB inhibitors. The model is supported by studies showing that IGF-IR activates Akt to repress GSK-3β, GSK-3β is a repressor of NF-κB activity and Snail mRNA and protein levels, IGF-IR activates NF-κB, and NF-κB binds the Snail promoter and increases Snail mRNA levels. PI3K, phosphatidylinositol 3-kinase.

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