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Specific interdependency of the PeBoW components. (A) H1299 cells were transfected two times with the indicated siRNAs. Effects on the Pes1, Bop1, and WDR12 protein levels were monitored at day 3 after the last transfection by Western blot analysis. (B) A schematic overview of the interdependency of the PeBoW components Pes1, Bop1, and WDR12 is shown. The number of arrows indicates the extent of downregulation.
