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. 2007 Mar 5;27(10):3695–3707. doi: 10.1128/MCB.01630-06

FIG. 2.

FIG. 2.

The sy262 mutation maps to the Dbl domain of SOS-1. (A) SNP mapping of sy262. Five out of nine Unc non-sy262 recombinants did not pick up the SNP located at position 9725 of cosmid F41F3, indicating that sy262 is to the left of cosmid F41F3. All the recombinants picked up the SNP at 14897 in the YAC Y61A9LA, which is next to the sos-1 gene. Thus, the sy262 mutation is close to the sos-1 locus. (B) Architecture of the C. elegans SOS-1 protein (GenBank accession number AF251308) and location of the sy262 mutation. The numbers refer to amino acid positions. Domain boundaries were determined by SMART (http://smart.embl-heidelberg.de/), except for the REM domain, whose position was determined by a BLAST (http://www.ncbi.nlm.nih.gov/BLAST/) alignment with hSOS1.