TABLE 5.
Magnitude of inhibition of the SOS-1 Dbl domain, c-Cbl, RasGAP, and MAPK phosphatase on the EGFR pathway
| Genotypea | Vulval inductionb | % Muvc | % Vuld | ne | P valuef |
|---|---|---|---|---|---|
| let-23(rf) | 0.23 | 0 | 100 | 20 | |
| sli-1(null) | 3.00 | 0 | 0 | 24 | |
| let-23(rf); sli-1(null) | 3.57 | 60 | 17 | 30 | <0.00001 to let-23(rf) |
| gap-1(null) | 3.00 | 0 | 0 | 36 | |
| let-23(rf); gap-1(null) | 3.74 | 71 | 0 | 21 | <0.00001 to let-23(rf) |
| lip-1(null) | 3.00 | 0 | 0 | 20 | |
| let-23(rf); lip-1(null) | 2.10 | 0 | 52 | 21 | <0.00001 to let-23(rf) |
| sy262 | 3.00 | 0 | 0 | 24 | |
| let-23(rf); sy262 | 3.80 | 68 | 0 | 22 | 0.34 to let-23(rf); sli-1(null), 0.80 to let-23(rf); gap-1(null), and <0.00001 to let-23(rf); lip-1(null) |
| sy262; gap-1(null) | 3.26 | 26 | 0 | 35 | 0.004 to gap-1(null) and sy262 |
a
let-23(rf) = let-23(sy1), and sli-1(null) = sli-1(sy143). The complete genotype of gap-1(null) is gap-1(n1691) unc-2(e55). lip-1(null) = lip-1(zh15); sy262 was linked to him-5(e1490).
b
Average number of vulval progenitor cells adopting vulval fates. Wild type is three. The maximum is six.
c
Percentage of animals with more than three vulval progenitor cells adopting vulval fates.
d
Percentage of animals with fewer than three vulval progenitor cells adopting vulval fates.
e
n, number of animals examined.
f
The statistical significance for the vulval induction value was determine using a two-tailed Student's t test.