FIG. 9.

Delayed maturation of the skin in cPGES/p23^−/− embryos. Aberrations in differentiation and formation of the cornified envelope in cPGES/p23^−/− stratified epithelia are shown. Skin from wild-type and cPGES/p23^−/− E17.5 and E18.5 fetuses was fixed in formalin and embedded in paraffin, and sections were cut (5 μm) and stained with hematoxylin and eosin. Sections correspond to the dorsal skin above the scapular region of the embryo. SC, stratum corneum; GR, granular layer; KG, keratohyaline granules; SP, suprabasal layer; BL, basal layer; DE, dermis.