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. 2007 Apr 2;27(12):4526–4540. doi: 10.1128/MCB.01724-06

FIG. 5.

FIG. 5.

CIF-1 is an evolutionarily conserved eIF3m-like subunit related to Csn7. (A) The domain organizations of CIF-1 and Csn7 family members (H. sapiens [H.s] Csn7a and D. melanogaster [D.m] Dch7) are compared. Similarities span the PCI domain and the region immediately upstream. The positions of the PCI domains were defined by SMART. A multiple alignment of the PCI domains and the residues located upstream from Csn7 family members (H. sapiens and D. melanogaster) CIF-1 is presented. (B) The CIF-1 protein sequence was aligned with human GA17 and D. melanogaster CG8309 using ClustalW. The alignment was shaded with BOXSHADE. (C) A phylogenetic analysis of Csn7 and GA17/eIF3m family members is represented. Csn7 protein sequences from human (Csn7a/Csn7b), D. melanogaster, A. thaliana (Fus5) (A. t), and S. pombe Csn7 (S. p) are shown in the upper part (CSN), while GA17/eIF3m protein sequences are presented in the lower part (eIF3).