TABLE 1.
Detection of RRV by culture and then EIA in organs from RRV-infected infant NOD mice
| Day postinfection and inoculation | % Positive (no. positive/no. tested) in:
|
||
|---|---|---|---|
| Intestine | Liver | Pancreasa | |
| 2 | |||
| Oral | 87 (13/15) | 27 (4/15) | 0 (0/15)b |
| i.p. | 100 (7/7) | 83 (5/6) | 0 (0/7) |
| 3 | |||
| Oral | 100 (16/16) | 33 (5/15) | 0 (0/16) |
| i.p. | 67 (10/15) | 71 (10/14) | 7-50 (1/14-7/14)a,c |
| 4 | |||
| Oral | 92 (12/13) | 0 (0/13) | 0 (0/13) |
| i.p. | 93 (13/14) | 67 (8/12) | 0 (0/14) |
| 5 | |||
| Oral | 88 (7/8) | 13 (1/8) | 25-100 (2/8-8/8)a,d |
| i.p. | 88 (7/8) | 50 (4/8) | 0 (0/8) |
a
Pancreases were assayed as pools of four to eight organs due to their small size in infant mice. Thus, a range from a single pancreas to all pancreases in the pool could be positive for RRV. This range is provided as a number and percentage.
b
From 7 to 60% (1/15 to 8/15) of these pancreases contained RRV antigen.
c
RRV antigen was not detected in these pancreases.
d
All of these pancreases (8/8) contained RRV antigen.