TABLE 5.
Summary of the effects of RRV infection in infant and young adult NOD mice
| Infection or disease parameter | Result for:
|
||
|---|---|---|---|
| Infants | Young adults
|
||
| Oral | i.p. | ||
| Gastrointestinal disease | Yes | No | No |
| Mice with detectable intestinal rotavirus replication (%) | 100 | 73 | 78 |
| Extraintestinal rotavirus | Yes | No | Yes |
| Pancreatic rotavirus | Low titer, antigen in macrophages outside islets | No | Low titer |
| Insulitis | |||
| 12 wk of age | Trend toward reduction for oral, not tested for i.p. | Not tested | Not tested |
| 30 wk of age | No alteration | Possible reduction | No effect |
| Diabetes onset | Delayed | No effect | Delayed |
| Diabetes incidence at 30 wk of age | Reduced | No effect | Reduced |
| Relationship between antibody titer and diabetes delay | Yes for oral, no for i.p. | No | No |