FIG. 4.
Env evolution in animal C640. The amino acid changes in viral Env gp120 over time in animal C640 are indicated. The numbering is based on the SF162 Env sequence. The numbers shown on the right of each sequence indicate the number of Env clones with that particular sequence, compared to SF162 Env, out of the indicated total number of Env clones amplified from PBMC and sequenced from the indicated day of infection. Sequence changes over time are compared to the HIV-1 SF162 Env sequence, which is similar to that of SHIVSF162P4. Highlighted in gray are the positions of potential N-linked glycosylation sites.