TABLE 3.
Serum cross-reactive neutralizing antibody responses in SHIVSF162P4-infected macaques and HIV-1 chronically infected humansa
| Parameter | SHIV-infected macaques
|
HIV-infected humans
|
|||||||
|---|---|---|---|---|---|---|---|---|---|
| C640 | A141 | P2 | P5 | P10 | P23 | P11 | P4 | P14 | |
| Approximate duration (in yr) of infection | 2 | 2 | 20 | 21 | 18 | 19 | 17 | 23 | 20 |
| Median viral load (log10) | 5 | 3.2 | 3.3 | UDc | UD | UD | 5.1 | 4.1 | 3.3 |
| % Neutralization for virus | |||||||||
| SF162 | 99 | 97 | 85 | 78 | 93 | 99 | 93 | 95 | 99 |
| ADA | 81 | (-) | (-) | 40 | (-) | 93 | 74 | 95 | (-) |
| JRFL | 95 | (-) | (-) | (-) | (-) | (-) | 99 | 86 | (-) |
| YU2 | 87 | (-) | (-) | (-) | (-) | 55 | 73 | 80 | (-) |
| HXB2 | 98 | (-) | 95 | 80 | 97 | 98 | 99 | 95 | |
| 3988 | 65 | (-) | (-) | (-) | (-) | 95 | (-) | 99 | (-) |
| 6101 | 53 | 57 | (-) | (-) | (-) | (-) | (-) | (-) | (-) |
| PVO.4 | 65 | (-) | (-) | (-) | (-) | (-) | (-) | (-) | |
| QH 0692 | 59 | 75 | (-) | (-) | (-) | (-) | 80 | (-) | (-) |
| REJO.67 | 53 | 68 | (-) | (-) | (-) | (-) | (-) | 82 | (-) |
| SC422661 | 76 | (-) | (-) | (-) | (-) | (-) | (-) | 94 | (-) |
| SS 1196 | 77 | 91 | (-) | 52 | 99 | 97 | 72 | 99 | (-) |
| TRO11 | 66 | 53 | (-) | 95 | (-) | (-) | (-) | 80 | (-) |
| TRJO | 56 | (-) | (-) | (-) | (-) | (-) | 80 | 93 | (-) |
| 5768 | (-) | (-) | (-) | (-) | (-) | 76 | (-) | 85 | (-) |
| 7165 | (-) | 63 | (-) | (-) | (-) | (-) | (-) | (-) | (-) |
| AR29 | (-) | (-) | (-) | (-) | (-) | (-) | (-) | (-) | (-) |
| BG 1168 | (-) | (-) | 75 | (-) | 68 | 78 | (-) | 80 | (-) |
| CAAN.A2 | (-) | (-) | (-) | (-) | (-) | (-) | (-) | (-) | (-) |
| QH 0515 | (-) | (-) | (-) | (-) | (-) | (-) | (-) | (-) | (-) |
| RHPA | (-) | (-) | (-) | (-) | (-) | (-) | (-) | 98 | (-) |
| Ratiod | 13/20 | 6/20 | 3/21 | 5/21 | 4/21 | 8/21 | 8/21 | 13/21 | 2/21 |
a
Sera from the indicated macaques (C640 and A141) and humans (P2, P5, P10, P23, P11, P4, and P14) were tested at a 1:20 dilution against the indicated viruses. The percent neutralization values were recorded.
b-, neutralization was not detected.
c
UD, undetectable viral load (<25 copies/ml).
d
The numbers at the bottom of the table indicate the numbers of heterologous isolates tested that were susceptible to neutralization by each serum/total number of isolates tested.