TABLE 4.
Relative titers of cross-reactive NAbs in macaque and human sera
| Virus | Serum dilutiona
|
||
|---|---|---|---|
| C640 (643 dpi) | A141 (670 dpi) | N16b | |
| 92HT593 | 89 | 19 | 157 |
| 92HT594 | 50 | 28 | 20 |
| 92US712 | 221 | 116 | 152 |
| BAL | 476 | 131 | 305 |
| BX08 | 706 | 366 | 403 |
| JRCSF | 69 | <10 | 234 |
| MN | 2,889 | 4,056 | 1,622 |
| NL43 | 1,072 | 1,142 | 2,086 |
| QZ5489 | 488 | 111 | 197 |
| MLV | 24 | <10 | 14 |
a
The values indicate the serum dilution that resulted in 50% inhibition of infection. MLV was used as control for nonspecific neutralization. Neutralization was considered significant (values in boldface) when the value was at least three times the value obtained with the unrelated MLV virus. The dpi was the day at which the animals were euthanized.
b
N16 sera was from a chronically HIV-1-infected nonprogressor that developed broadly reactive anti-HIV-1 NAbs (2).