TABLE 1.
Microscopic findings in Lassa virus-infected marmosets
| Tissue/pathology | Finding for indicated dose and animala
|
|||
|---|---|---|---|---|
| 103 PFU
|
106 PFU
|
|||
| 17102 | 18164 | 17280 | 18810 | |
| Liver | ||||
| Hepatitis | ++ | ++ | + | ++ |
| Eosinophilic inclusions | + | + | + | + |
| Biliary stasis | + | + | − | + |
| Hepatic necrosis | + | + | + | + |
| Portal infiltrates | − | + | − | + |
| Lymphoid and hematopoietic | ||||
| Lymph node lymphadenopathy | + | + | + | + |
| Spleen, lymphoid depletion | + | + | + | + |
| Bone marrow | NSF | NSF | NSF | NSF |
| Kidney | ||||
| Interstitial nephritis | ++ | + | + | + |
| Mesangial thickening | + | + | + | + |
| Protein casts | + | + | + | + |
| Gastrointestinal system | ||||
| Stomach | NSF | NSF | NSF | NSF |
| Salivary gland | NE | NSF | NSF | NSF |
| Pancreas | NSF | NE | NSF | NSF |
| Large intestine | NSF | NSF | NSF | NSF |
| Small intestine | NSF | NSF | NSF | NSF |
| Lung | ||||
| Interstitial pneumonitis | − | − | + | + |
| Pulmonary edema | − | − | + | + |
| Mesothelial hypertrophy | − | − | + | + |
| Other tissues | ||||
| Necrosis in adrenal gland | NE | + | NE | + |
| Brain | NSF | NSF | NSF | NSF |
| Heart | NSF | NSF | NSF | NE |
| Skin | NSF | NSF | NSF | NSF |
a
+, mild to moderate; ++, moderate to severe; −, absent; NE, not examined; NSF, no significant findings.