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Western blot analysis of brains of CD11c-N17Rac1 mice and wild-type mice inoculated intraperitoneally and orally with the RML prion strain. Brain material was electrophoresed without (−) or after digestion with proteinase K (+). Large amounts of PK-resistant prion protein (PrPSc) were detected in all mice that developed prion disease. WT, wild type.
