FIG. 1.
Deposition of PrPd in select tissues taken from infected (A, C, E, G, and I) and mock-infected (B, D, F, H, and J) hamsters at 22 weeks after e.n. inoculation. IHC using an antibody to the prion protein was used to identify PrPd. Matched pairs of tissue sections of the NALT (A and B; NALT outlined by dashed lines), a follicle in the submandibular lymph (C and D; outer edge of follicle outlined by dashed line), white pulp nodule of the spleen (E and F), Peyer's patch (G and H), and a fungiform papillae of the tongue (I and J; base of taste bud outlined by dashed line) from infected and mock-infected hamsters that were processed identically. Note the punctate deposits of PrPd that were seen only in tissues of hamsters that were inoculated e.n. with HY TME and the lack of PrPd in the same tissues taken from the e.n. mock-infected hamsters. Bar, 50 μm.