FIG. 4.
PrPd in lymph nodes after e.n. inoculation. (A) Low-power view of PrPd in multiple follicles (indicated by arrows) of a submandibular lymph node of a hamster 14 weeks after e.n. inoculation. (B) High-power view of the area outlined by the box in panel A. The PrPd is located in, or on, cells and cell processes between the lymphocytes of the submandibular lymph node. (C) Low-power view of a cervical lymph node of a hamster at 22 weeks postinoculation. Note the PrPd is found in only two follicles (box and arrow). (D) High-power view of PrPd in the area outlined by the box in panel C. PrPd is located between the lymphocytes of the follicle. (E) Low-power view of a mesenteric lymph node of a hamster at 22 weeks postinoculation. Note that the PrPd is limited to two follicles (box and arrow). (F) High-power view of PrPd in the area outlined by the box in panel E. Note the punctate staining located between the lymphocytes of the follicle. Bars: A, 500 μm; C and E, 200 μm; B, D, and F, 50 μm.