TABLE 1.
Summary of gB mutant propertiesa
Mutation(s) | Fusion loop | Expression in L cells | MAb reactivity
|
Surface expression
|
Fusion
|
|||||
---|---|---|---|---|---|---|---|---|---|---|
DL16 | SS55 | SS145 | Anti-Myc | IFA | CELISA (% WT) | Luc (% WT) | Syncytia | |||
None | + | + | + | + | − | + | 100 | 100 | + | |
W174Y | I | + | + | + | + | − | + | 123 ± 47 | 46 ± 14 | − |
W174K | I | + | − | − | − | − | + | 55 ± 23 | 0 ± 0.25 | − |
W174R | I | + | + | + | + | − | + | 146 ± 57 | 9 ± 14 | − |
Y179K | I | + | + | + | + | − | + | 142 ± 45 | 0 ± 10 | − |
V259R | II | + | − | − | − | − | − | 22 ± 23 | 4 ± 4 | − |
A261W | II | + | + | + | + | − | + | 108 ± 60 | 18 ± 16 | − |
A261D | II | + | + | + | + | − | + | 125 ± 50 | 9 ± 8 | − |
W174R/A261D | I and II | + | + | + | + | − | + | 162 ± 10 | 0 ± 10 | − |
F262L | II | + | + | + | + | − | + | 105 ± 59 | 68 ± 21 | + |
F262D | II | + | + | + | + | − | + | 103 ± 57 | 115 ± 23 | + |
IFA, immunofluorescence assay; Luc, luciferase.