TABLE 1.
Replicon name | Cell line description | IC50 (μM) | Mutation(s) in NS5B |
---|---|---|---|
GS5 | Control | 0.22 ± 0.04 | NA |
RS2 | Resistant cell pool | 2.4 ± 0.8 | I432V, K535N |
RS1-2 | Resistant single clone | 2.2 ± 0.8 | I432V |
IC50, 50% inhibitory concentration; NA, not applicable.