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Mutations in NS5B identified in CsA-resistant GT1b replicons
| Replicon name | Cell line description | IC50 (μM) | Mutation(s) in NS5B |
|---|---|---|---|
| GS5 | Control | 0.22 ± 0.04 | NA |
| RS2 | Resistant cell pool | 2.4 ± 0.8 | I432V, K535N |
| RS1-2 | Resistant single clone | 2.2 ± 0.8 | I432V |
IC50, 50% inhibitory concentration; NA, not applicable.
