FIG. 4.
Phylogenetically conserved RNA structure in the 3CPro ORF associated with the inhibition of RNase L. PV RNA sequences corresponding to ORF 2122 were aligned with RNA sequences of related group C enteroviruses. (A) Stem-loop 1 and stem-loop 4. (B) “Connector” region. Asterisks indicate wobble positions of codons. Nucleotides highlighted with gray circles are inconsistent with base pairing in PV ORF 2122. Viruses and nucleotide accession numbers are as follows: PV1, NC 002058; PV2, M12197; PV3, K01392; CA11, AF499636; CA17, AF499639; CA20, AF499642; CA13, AF499637; CA21, AF546702; and CA24, D90457.