TABLE 1.
Pathways regulated by RSV infection and genes regulated in these pathwaysa
| Pathway | Products of genes regulated by RSV infection |
|---|---|
| TLR signaling pathway | Tlr1, Tlr2, CD14, IκB, RelB, IL-6, Cxcl10, Cxcl11, Ccl11, Ccl20 |
| IL-1 signaling pathway | IL-1b, I-κBe, RelB, IRF1, F3, Edn1, serpine 1 |
| IFN-α/β signaling pathway | Stat1, Stat2, Irf9, Ifit2, Gip2 |
| IFN-γ signaling pathway | IFN-γ, Socs1, Stat1, CamK2B, IRF1, IRF9, Pkr, Icam1 |
| RhoA regulation pathway | IRF9, Stat1, Stat2, Oas1, Pkr |
| Caspase cascade activation by FADD and RIPK | Bid, Tnfaip33, Birc2, Birc3, RipK1 |
| Tumor necrosis factor receptor 1 signaling in apoptosis | Arts-1, caspase 8, Bid, Birc2, Birc3, RelB, IκBe, RipK1 |
| IAP proteins in apoptosis | Caspase 8, Hsp70, Birc2, Birc3, survivin, Cdc2 |
| Antiapoptotic tumor necrosis factor/NF-κB/IAP pathway | Birc2, Birc3, survivin, RelB, IκBe, RipK1 |
a
Data were obtained using MetaCore analysis.