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. 2007 Mar 21;81(11):5958–5967. doi: 10.1128/JVI.02220-06

TABLE 3.

Genes up-regulated by infection with RSV that can be classified as being involved in chemoattraction, the IFN response, and inflammation

Category and gene productc Description Fold change on:
Day 1a Day 3b
Chemoattraction
    Cxcl10* Chemokine (C-X-C motif) ligand 10 9.66 1.50
    Ccl2 Chemokine (C-C motif) ligand 2 9.26 1.94
    Cxcl11* Chemokine (C-X-C motif) ligand 11 7.94 1.96
    Cxcl1 Chemokine (C-X-C motif) ligand 1 7.67 2.46
    Ccl7 Chemokine (C-C motif) ligand 7 5.47 1.63
    Ccl4* Chemokine (C-C motif) ligand 4 2.86 1.73
    Cxcl2 Chemokine (C-X-C motif) ligand 2 2.66 1.22
    Ccl9 Chemokine (C-C motif) ligand 9 2.30 2.67
    Cxcl9* Chemokine (C-X-C motif) ligand 9 2.29 1.23
    Cxcl5 Chemokine (C-X-C motif) ligand 5 2.03 1.50
    Rgs1 Regulator of G-protein signaling 1 2.03 1.41
    Ccr7 Chemokine (C-C motif) receptor 7 2.01 1.57
    Ccl8 Chemokine (C-C motif) ligand 8 1.92 2.84
Interferon response
    G1p2 Interferon-alpha-inducible protein 17.33 4.69
    Ifi44 Interferon-induced protein 44 16.67 4.47
    Ifit1 Interferon-induced protein with tetratricopeptide repeats 1 13.36 3.15
    Ifi202b Interferon-activated gene 202B 9.79 4.19
    Ifit3 Interferon-induced protein with tetratricopeptide repeats 3 9.02 2.63
    Ifi204 Interferon-activated gene 204 8.61 2.97
    Herc5 Hect domain and RLD5 6.84 2.02
    Ifi1* Interferon-inducible protein 1 6.77 2.25
    Irf7 Interferon regulatory factor 7 6.72 4.95
    Stat1* Signal transducer and activator of transcription 1 6.70 2.48
    Ifih1 Interferon induced with helicase C domain 1 6.47 2.28
    Ifit2 Interferon-induced protein with tetratricopeptide repeats 2 5.95 1.25
    Gbp2 Guanylate nucleotide binding protein 2 5.82 1.48
    Rtp4 RIKEN cDNA 5830458K16 gene 5.58 3.01
    Isg20 Interferon-stimulated protein 4.81 1.71
    Ifi203 Interferon-activated gene 203 4.27 1.91
    Iigp2 Interferon-inducible GTPase 2 4.22 1.64
    Ifi27 Interferon alpha-inducible protein 27 4.20 6.93
    Igtp* Interferon-gamma-induced GTPase 4.20 1.44
    Stat2* Signal transducer and activator of transcription 2 4.02 1.95
    Usp18 Ubiquitin-specific protease 18 4.01 1.80
    Oas1a 2′-5′ Oligoadenylate synthetase 1A 3.68 2.24
    Daxx Fas death domain-associated protein 3.67 1.39
    Ifi35* Interferon-induced protein 35 3.07 1.44
    Nmi* N-myc (and STAT) interactor 2.96 1.37
    Ifi47* Interferon-gamma-inducible protein 47 2.75 1.34
    Gbp1 Guanylate nucleotide binding protein 1 2.71 1.31
    Prkr Protein kinase, interferon-inducible double-stranded RNA dependent 2.60 1.32
    Ifitm3 Interferon-induced transmembrane protein 3 2.49 1.87
    Cd69* CD69 antigen 2.38 1.14
    Ube1l Ubiquitin-activating enzyme E1-like 2.31 1.31
    Isgf3g Interferon-dependent positive-acting transcription factor 3 gamma 2.17 1.60
    Fcgr1* Fc receptor, IgG, high-affinity I 2.05 1.66
    Aif1* Allograft inflammatory factor 1 2.04 1.79
Inflammation
    Tgtp T-cell-specific GTPase 10.60 2.65
    Gbp4 Guanylate nucleotide binding protein 4 9.79 2.76
    Tyki Thymidylate kinase family LPS-inducible member 7.90 1.66
    Il6 Interleukin-6 4.77 1.22
    Lcn2 Lipocalin 2 4.59 6.08
    Il18bp* Interleukin-18 binding protein 4.07 1.63
    Lilrb4 Leukocyte Ig-like receptor, subfamily B, member 4 3.80 2.52
    Il1rn Interleukin-1 receptor antagonist 3.25 1.37
    Timp1 Tissue inhibitor of metalloproteinase 1 3.14 1.93
    Irg1 Immunoresponsive gene 1 3.04 1.38
    Alox12 Arachidonate 12-lipoxygenase 2.74 3.43
    Asb15 Ankyrin repeat and SOCS box-containing protein 15 2.73 1.14
    Mpa2 Macrophage activation 2 2.73 1.49
    Samhd1 SAM domain and HD domain 1 2.66 1.37
    IL-15 Interleukin-15 2.63 1.17
    Cd19 CD19 antigen 2.49 1.17
    IL-1b Interleukin 1 beta 2.43 1.52
    Casp11 Caspase 11, apoptosis-related cysteine protease 2.36 1.40
    Tlr2 Toll-like receptor 2 2.36 1.41
    Ear4** Eosinophil-associated, RNase A family, member 4 2.35 1.13
    Fcer1g** Fc receptor, IgE, high-affinity I, gamma polypeptide 2.32 2.17
    Il1rl1 Interleukin 1 receptor-like 1 2.32 1.38
    Cd14 CD14 antigen 2.29 1.91
    Gzmb Granzyme B 2.18 1.36
    Ankrd1 Ankyrin repeat domain 1 (cardiac muscle) 2.15 1.33
    Tlr3 Toll-like receptor 3 2.11 1.06
    Gata3** GATA binding protein 3 2.10 1.29
    Cd274 CD274 antigen 2.06 1.06
    Osmr Oncostatin M receptor 2.05 −1.01
    Clec4e C-type lectin domain family 4, member e 2.04 1.11
    C2 Complement component 2 (within H-2S) 2.03 1.80
    Zc3hav1 Zinc finger CCCH type, antiviral 1 2.02 1.41
    Cd83 CD83 antigen 2.02 1.46
    Ig region Ig region 2.01 1.36
    Lrg1 Leucine-rich alpha-2-glycoprotein 1 2.01 1.78
    C3 Complement component 3 1.79 2.06
    Ly64 Lymphocyte antigen 64 1.71 2.03
    C3ar1** Complement component 3a receptor 1 1.48 3.05
    Cd72 CD72 antigen 1.43 3.90
    Clec7a C-type lectin domain family 7, member a 1.39 2.71
Antigen processing and presentation
    Psmb10* Proteasome (prosome, macropain) subunit, beta type 10 2.39 1.30
    Psmb8* Proteasome (prosome, macropain) subunit, beta type 8 3.05 1.93
    Psme1* Proteasome (prosome, macropain) 28 subunit alpha 2.35 1.41
    Psme2* Proteasome (prosome, macropain) 28 subunit beta 2.51 1.48
    Tap2 Transporter 2, ATP-binding cassette, subfamily B (MDR/TAP) 2.56 1.21
    n = 7 genes MHC class I molecule/genes 2.42 2.42
    n = 5 genes* MHC class II molecule/genes 2.46 2.94
a

Change (n-fold) in regulation compared to that for mock infection on day 1.

b

Change (n-fold) in regulation compared to that for mock infection on day 3.

c

Gene products with * are products of Th1-associated genes, and those with ** are products of Th2-associated genes.