FIG. 5.

The magnitude of IFN-γ responses was greater in older infants. There was no correlation between age at the time of diagnosis and the magnitude of IFN-γ response in those cases where a peptide induced a peptide-specific response (A) immediately after diagnosis or (B) 4 months later, but (C) there was a positive correlation by 12 months following diagnosis. (D) Samples collected from subjects between 40 and 60 weeks of age who had been infected 4 months previously had an IFN-γ response similar to that of infants who had been infected 12 months previously. The bars indicate means. (E) Twelve-month samples were collected from infants diagnosed with CMV at 4 to 10 weeks when they reached 40 to 60 weeks of age, and 4-month samples were collected from infants diagnosed at 17 to 39 weeks when they reached the same age. When the 4- and 12-month samples from subjects who fell into either of these two categories were compared, a greater IFN-γ response was elicited from the 12-month sample in nearly all cases. The absence of a bar indicates that the sample was collected but no response was detected.