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The sequence of regions of HPV E4 proteins that are rich in basic amino acids. The amino acid sequences of E4 regions of HPV1, -16, -18, and -63 that are particularly rich in basic amino acids are shown with arginine residues identified in boldface type. Note that bipartite arginine-rich motifs are present in HPV1, -18, and -63 but not HPV16. Amino acids within the HPV1 E4 region involved in the interaction with SRPK1 are underlined.
