TABLE 3.
Results of the single-dose NaB-PBS treatment regimen administered to mice with latent HSV-1 McKrae infectiona
| Mouse group | NaB dose (mg/kg/100 μl) | No. of positive swabs/total no. of swabs | No. of positive TG/total no. of TG | No. of deaths/no. of mice in group |
|---|---|---|---|---|
| 1 | 1,200 | 5/16 | 6/8 | 1/4 |
| 2 | 600 | 0/16 | 0/8 | 0/4 |
| 3 | 400 | 0/16 | 0/8 | 0/4 |
| 4 | 200 | 0/16 | 0/8 | 0/4 |
| 5 (control) | 0 | 0/16 | 0/8 | 0/4 |
a
Mice were given intraperitoneal doses of NaB ranging from 1,200 to 200 mg/kg in PBS. Eyes were swabbed prior to the onset of the experiment and at 72 h postinjection. The total number of eye swabs includes swabs taken before NaB-PBS treatment. At 72 h post-NaB-PBS administration, mice were sacrificed and their TG were harvested. TG were homogenized and pelleted, and the supernatant was plated onto PRK cells. The presence of infectious virus was indicated by CPE.