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. Author manuscript; available in PMC: 2008 Jan 1.
Published in final edited form as: Neurobiol Dis. 2006 Oct 9;25(1):80–91. doi: 10.1016/j.nbd.2006.08.015

Figure 3. CRE-mediated gene expression in reactive astrocytes.

Figure 3

Animals were sacrificed either 4 hrs or 48 hrs after pilocarpine-evoked SE. A) Representative GFAP immunolabeling from the hippocampus reveals that SE triggered a marked upregulation of GFAP labeling relative to control conditions. B) Tissue was fluorescently immunolabeled for β-galactosidase (green) and GFAP (red). Four hrs after SE, β-galactosidase expression was observed in the granule cell layer (GCL). In contrast, limited β-galactosidase expression was detected in GFAP positive cells at this time point. By 48 hrs post-seizure onset, β-galactosidase expression was observed in astrocytes throughout the dentate gyrus. hil: hilus, mol: molecular layer.