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. 1998 Feb 17;95(4):1369–1374. doi: 10.1073/pnas.95.4.1369

Figure 1.

Figure 1

Growth inhibition assays of FTI and chemotherapy combinations. MCF-7 and MDA- MB-468 breast cancer cells were seeded at 10,000 and 20,000 cells per well and the following day were exposed to the stated chemotherapeutic agent for 4 h. Cells then were washed and placed in media containing the FTI L-744832 [Merck (6)] and incubated for 7–10 days. Cells then were harvested by trypsinization and counted in a Coulter counter. The assays were performed at doses of chemotherapy and FTI that show only modest growth inhibition by themselves to best evaluate additive effects. Combinations of FTI with doxorubicin, cisplatin, and vinblastine are shown for MDA-MB-468 (A) and MCF-7 (B) cells. The growth-suppressive effects of FTI alone also are depicted on the right for comparison.