[Fo − Fc] electron density of CTE (belonging to chain O) was calculated, omitting the CTE residues and shown at 2.5 σ cutoff. The disulphide bridge between Cys-349 and Cys-358 and distances below 5 Å between CTE residues and protein residues or ligands are also shown (see also SI Table 1). Atom color codes: carbon, yellow; oxygen, red; nitrogen, blue; sulfur, green; phosphorus, violet. The image was produced by Xtalview (37) and rendered by Raster3D (32).