Table 2.
Analysis of HERV-KX sequences with Locus Assigner and RECCO.
1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 |
HERV-KX sequence | Locus- Assigner | # diff's | # recom's | loci involved | recom region | # diff's to locus | p value | # diff's after recom |
B251 (*) | 7_450 | 56 | 3 | 3_610/5_147/7_345 | 59–67 | 0 | 0,059 | |
7_450 | 182–191 | 0 | 0,001 | |||||
10_019 1_504/K115/19_352 |
385–436 | 3 1 |
0,023 | 4 | ||||
B251 (*) | 7_450 | 56 | 2 | 7_450 | 182–191 | 6 | 0,001 | |
10_019 | 385–436 | 3 | 0,023 | |||||
1_504/K1_15/19_352 | 1 | 10 | ||||||
B251 (*) | 7_450 | 56 | 1 | 7_450 | 182–191 | 6 | 0,001 | |
10_019 | 14 | 20 | ||||||
B100 | 7_450 | 54 | 2 | 7_450 | 164–181 | 0 | 0,001 | |
3_385 7_345 |
510–551 | 0 0 |
0,004 | 0 | ||||
B260 | 7_450 | 53 | 1 | 7_450 | 164–181 | 0 | 0,001 | |
5_544 | 4 | 4 | ||||||
B81 | 7_450 | 52 | 1 | 7_450 | 192–205 | 1 | 0,001 | |
1_259 | 6 | 7 | ||||||
108 (**) | 3_610 | 51 | 1 | 21_019 | 68–181 | 0 | 0,001 | |
7_450 | 0 | 0 | ||||||
B83 (*) | 7_450 | 51 | 2 | 7_450 | 192–209 | 3 | 0,001 | |
10_019 | 437–466 | 2 | 0,201 | |||||
1_504/19_352/K115 | 2 | 7 | ||||||
B83 (*) | 7_450 | 51 | 1 | 7_450 | 192–209 | 3 | 0,001 | |
10_019 | 13 | 16 | ||||||
B358 (**) | 11_424/3_354/1_504/5_544/K115 | 50 | 2 | 5_544 | 68–181 | 2 | 0,001 | |
7_450 | 727–752 | 0 | 0,004 | |||||
3_385 | 0 | 2 | ||||||
B269 (**) | 3_610 | 48 | 1 | 3_610/7_345/5_147 | 68–181 | 0 | 0,001 | |
7_450 | 0 | 0 | ||||||
B281 | 7_450 | 43 | 1 | 7_450 | 238–242 | 0 | 0,001 | |
1_504/1_259 | 4 | 4 | ||||||
B268 (*) | 7_450 | 41 | 2 | 7_450 | 164–181 | 0 | 0,001 | |
1_504/22_012/6_324 | 583–712 | 0 | 0,122 | |||||
7_450 | 0 | 0 | ||||||
B268 (*) | 7_450 | 41 | 1 | 7_450 1_504/22_012/6_324 |
164–181 | 0 6 |
0,001 | |
B270 | 7_450 | 39 | 2 | 7_450 | 267–273 | 0 | 0,001 | |
3_385 | 502–505 | 0 | 0,001 | |||||
3_014 | 0 | 0 | ||||||
B282 | 1_504 | 36 | 2 | 3_354/1_504 | 238–242 | 1 | 0,001 | |
7_450 | 583–712 | 0 | 0,004 | |||||
3_385 | 0 | 1 | ||||||
B362 (*) | 1_259 | 31 | 2 | 11_424 | 389–401 | 2 | 0,001 | |
7_450 | 583–624 | 0 | 0,102 | |||||
10_019 | 0 | 2 | ||||||
B362 (*) | 1_259 | 31 | 1 | 11_424 | 389–401 | 2 | 0,001 | |
7_450 | 9 | 11 | ||||||
94 | 11_456 | 26 | 2 | 11_456 | 415–422 | 0 | 0,001 | |
7_450 | 583–651 | 0 | 0,003 | |||||
11_456 | 0 | 0 | ||||||
B98a | 3_496/7_345 | 20 | 1 | 10_019 | 214–263 | 2 | 0,001 | |
7_345/1_504 | 8 | 10 | ||||||
622 (*) | 3_014 | 19 | 2 | HOM/6_324 | 316–388 | 0 | 0,001 | |
3_014 | 676–764 | 0 | 0,330 | |||||
3_385 | 0 | 0 | ||||||
622 (*) | 3_014 | 19 | 1 | HOM/6_324 | 316–388 | 0 | 0,001 | |
3_014 | 5 | 5 | ||||||
B276 (*) | 1_504 | 18 | 2 | 3_354/1_504 | 192–306 | 0 | 0,021 | |
3_385 | 521–553 | 0 | 0,001 | |||||
7_450 | 0 | 0 | ||||||
B276 (*) | 1_504 | 18 | 1 | 3_385 | 521–553 | 5 | 0,001 | |
7_450 | 0 | 5 | ||||||
B188 | 11_424 | 18 | 3 | 1_259/11_424 | 256–265 | 0 | 0,006 | |
7_450 | 404–414 | 0 | 0,006 | |||||
(***) | 583–610 | 1 | 0,002 | |||||
7_450 | 0 | 1 | ||||||
B262 | 3_496 | 17 | 1 | 4_742 | 209–226 | 0 | 0,001 | |
5_544 | 4 | 4 | ||||||
B12 | 5_544 | 14 | 1 | 5 544 | 583–673 | 7 | 0,001 | |
7_450 | 0 | 7 | ||||||
93 | 7_450 | 13 | 1 | 7_450 | 583–610 | 1 | 0,001 | |
21 019 | 0 | 1 |
Designation of columns is the same as in Table 1.
(*) RECCO provided alternative explanations with different p-values. The lowest p-value did not neccessarily correspond to the explanation with the least nt differences. By visual inspection of sequences, another explanation may be favored despite a higher p-value.
(**) HERV-KX sequences without 96 bp sequence. RECCO predicted recombination with loci having the 96 bp sequence (see text), and predicted a recombination involving the 96 bp sequence. Regions of recombination events may therefore be shorter then the ones given by RECCO.
(***) Among 10 different proviral loci, RECCO does not specify a particular locus because all 10 loci are very similar or identical in sequence to each other in the concerned region. By visual inspection, a more optimal explanation among the 10 loci may be specified.