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. 2007 Jul 11;2(7):e607. doi: 10.1371/journal.pone.0000607

Figure 4. SRP-induced nucleotide specificity of FtsY.

Figure 4

The specificity-determining hydrogen bonding interactions between GMPPNP and Asp258 are on average 0.6 Å more distant in the (A) monomeric nucleotide bound form of FtsY (F1) than for (D) FtsY in complex with Ffh. This additional spacing allows for the non-specific binding and hydrolysis of (B) ATP and (C) XTP in the monomeric form but not the complexed form of FtsY as observed in biochemical studies by Shan and Walter [24]. The ATP and XTP molecules were modeled based on the position of GMPPNP in the monomeric form of FtsY (F1).