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Synthesis of CEM-admities. (i) 2-cyanoethyl methylthiomethyl ether, molecular sieves 4A (MS 4A), NIS, CF3SO3H, THF, −45°C; (ii) DMSO, acetic anhydride, acetic acid; (iii) 3-hydroxypropionitrile, MS 4A, NIS, CF3SO3H, THF, −45°C; (iv) NH4F, MeOH, 50°C or TEA·3HF, THF, 45°C; (v) 4,4′-dimethoxytrityl chloride, THF, pyridine, MS 4A, room temperature; (vi) diisopropylammonium tetrazolide, bis(N,N-diisopropylamino) cyanoethylphosphite, CH3CN, 40°C.
