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. 2007 Jul 2;117(7):1933–1939. doi: 10.1172/JCI31342

Figure 2. BMP-2 administration in mice increases hepcidin mRNA expression and decreases serum iron.

Figure 2

129S6/SvEvTac mice were injected retroorbitally with 1 mg/kg BMP-2 (n = 8) or an equal volume of vehicle alone (n = 7). Four hours after injection, blood and livers were harvested. (A) Total mRNA was isolated from livers and analyzed by quantitative real-time RT-PCR for hepcidin mRNA expression relative to expression of GAPDH mRNA, which was used as an internal control. (B) Serum iron was measured by colorimetric assay. Results are reported as the mean ± SD. *P = 0.02 for BMP-2–treated mice compared with controls.