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. 2007 Jul 2;117(7):1933–1939. doi: 10.1172/JCI31342

Figure 6. Soluble HJV.Fc inhibits IL-6 induction of hepcidin expression.

Figure 6

HepG2 cells were incubated for 16 hours alone (control), with 100 ng/ml IL-6, or with 100 ng/ml IL-6 in combination with HJV.Fc after pre-incubation with HJV.Fc for 1 hour. Total RNA was analyzed for hepcidin expression relative to β-actin expression by quantitative real-time RT-PCR. Results are expressed as mean ± SD, n = 3 per group; *P = 0.003 for IL-6–treated cells compared with control cells; †P = 0.0006 for cells treated with HJV.Fc in combination with IL-6 compared with cells treated with IL-6 alone.