Table 1.

Inhibitory activities of the adamantane-based ureas 1{1}, 2{1}, 3{1}, and 4{1} derived from the amines 1 to 4

Compounda	R2-NH2	IC50b(nM)	% inhibitionc
1{1}	1	0.5	86 ± 9
2{1}	2	0.5	75 ± 12
3{1}	3	30	19 ± 7
4{1}	4	100	10 ± 3

^aThe notation for the compound number: amine number {isocyanate number}, for example, 2{1} indicates a compound made by the combination of amine 2 with isocyanate 1.

^bAs determined via a kinetic fluorescent assay.¹⁰

^cDetermined via an end-point fluorescent assay, results are means ± SD of three separate experiments.¹¹